Baird D D, McConnaughey D R, Weinberg C R, Musey P I, Collins D C, Kesner J S, Knecht E A, Wilcox A J
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Epidemiology. 1995 Sep;6(5):547-50. doi: 10.1097/00001648-199509000-00015.
Longitudinal epidemiologic studies of menstrual and reproductive function are more informative if one can identify day of ovulation. We previously developed a method for estimating day of ovulation that is feasible for epidemiologic studies. The method relies on the relative concentrations of estrogen and progesterone metabolites in daily first-morning urine specimens and does not require creatinine adjustment. This paper describes results of applying this method to a large study with 724 menstrual cycles from 217 women. The method estimated a credible day of ovulation in 88% of cycles. Missing data accounted for most of the failures. When we excluded anovulatory cycles (1%) and cycles with missing data, the method estimated a day of ovulation in 97% of cycles. Variance in luteal phase length was small for our sample, suggesting that this method of identifying a day of ovulation introduces no more measurement error than when day of ovulation is determined by plasma luteinizing hormone (LH), the standard clinical method.
如果能够确定排卵日，那么对月经和生殖功能进行的纵向流行病学研究将更具参考价值。我们之前开发了一种估算排卵日的方法，该方法适用于流行病学研究。此方法依赖于每日晨尿样本中雌激素和孕激素代谢物的相对浓度，且无需进行肌酐校正。本文描述了将该方法应用于一项涉及217名女性的724个月经周期的大型研究的结果。该方法在88%的周期中估算出了可信的排卵日。数据缺失是导致大多数失败情况的原因。当我们排除无排卵周期（1%）和有数据缺失的周期后，该方法在97%的周期中估算出了排卵日。我们样本的黄体期长度差异较小，这表明这种确定排卵日的方法所引入的测量误差并不比采用标准临床方法——通过血浆促黄体生成素（LH）来确定排卵日时更大。
