使用小梁切除术来研究眼科伤口愈合的药理学调节。

The use of trabeculectomy to study the pharmacological modulation of ophthalmic wound healing.

作者信息

Schwade N D, Chiou G C

机构信息

Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station, USA.

出版信息

J Ocul Pharmacol Ther. 1995 Summer;11(2):113-23. doi: 10.1089/jop.1995.11.113.

DOI:10.1089/jop.1995.11.113

PMID:8564632

Abstract

A trabeculectomy model was developed to test the efficacy of a putative interleukin-1 blocker on the modulation of ophthalmic wound healing in the pigmented rabbit. The corticosteroid, methylprednisolone acetate, was used as a positive control and was effective in prolonging the time to failure of the trabeculectomy. The experimental compound CK-103A was found to be more efficacious than methyl prednisolone acetate. CK-103A increased the time of failure by 79%, with no side effects at the doses tested to date.

摘要

建立了小梁切除术模型，以测试一种假定的白细胞介素-1阻滞剂对色素兔眼伤口愈合调节的功效。皮质类固醇醋酸甲泼尼龙用作阳性对照，可有效延长小梁切除术失败的时间。发现实验化合物CK-103A比醋酸甲泼尼龙更有效。CK-103A使失败时间增加了79%，在迄今为止测试的剂量下没有副作用。