地西泮对小鼠吗啡诱导的位置偏爱效应的阻断作用。
Blockade of morphine-induced place preference by diazepam in mice.
作者信息
Suzuki T, Tsuda M, Funada M, Misawa M
机构信息
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
出版信息
Eur J Pharmacol. 1995 Jul 14;280(3):327-30. doi: 10.1016/0014-2999(95)00249-k.
The effects of diazepam on morphine-induced place preference were examined in mice. Pretreatment with diazepam (2 mg/kg i.p.) 30 min prior to morphine injection significantly abolished the morphine (5 mg/kg s.c.)-induced place preference, and this effect of diazepam was antagonized by pretreatment with flumazenil. In addition, pretreatment with diazepam prevented the morphine (5 mg/kg s.c.)-induced increase in dopamine turnover in the limbic forebrain. These results suggest that pretreatment with diazepam may suppress the rewarding effects of morphine.
研究了地西泮对小鼠吗啡诱导的位置偏爱效应的影响。在注射吗啡前30分钟腹腔注射地西泮（2毫克/千克），显著消除了吗啡（5毫克/千克皮下注射）诱导的位置偏爱，而地西泮的这种作用被氟马西尼预处理所拮抗。此外，地西泮预处理可防止吗啡（5毫克/千克皮下注射）诱导的边缘前脑多巴胺周转率增加。这些结果表明，地西泮预处理可能会抑制吗啡的奖赏效应。
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