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[维生素E对双侧膈下迷走神经切断术后大鼠肝脏线粒体功能状态的影响]

[Effect of vitamin E on the functional state of rat liver mitochondria following bilateral subdiaphragmatic vagotomy].

作者信息

Eletskiĭ Iu K, Zozulia A A

出版信息

Farmakol Toksikol. 1977 Jan-Feb;40(1):70-3.

PMID:856623
Abstract

On the basis of a proven protective effect of vitamin "E" in regard to cellular metabolism in hypoxia and presuming that it is exactly the chronic hypoxia that forms the main pathogenetic link in the development of "deneravation changes" the effect of vitamin "E" on the function of hepatic metachondria in rats was studied polarographically and by using tetracycline, as a fluorescent probe, at different dates following bilateral subphrenic vagotomy. The available data prompted an inference of a marked stabilizing influence of the agent on the state of mitochondria in 7 and more days after vagotomy.

摘要

基于维生素“E”对缺氧时细胞代谢具有已证实的保护作用,并假定正是慢性缺氧构成了“去神经支配变化”发展中的主要发病机制环节,本研究采用极谱法并使用四环素作为荧光探针,在双侧膈下迷走神经切断术后的不同时间,研究了维生素“E”对大鼠肝线粒体功能的影响。现有数据提示,该药物在迷走神经切断术后7天及更长时间对线粒体状态具有显著的稳定作用。

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