Zochodne D W, Murray M M, van der Sloot P, Riopelle R J
University of Calgary, Department of Clinical Neurosciences, Alberta, Canada.
Brain Res. 1995 Nov 6;698(1-2):130-6. doi: 10.1016/0006-8993(95)00876-r.
Using electrophysiological recordings, we studied a distal tibial mononeuropathy that involves the hind foot of rats reared in cages with wire grid flooring. In an initial set of experiments, serial sciatic-tibial motor conduction recordings were made in smaller or larger rats reared in cages with wire grid or sawdust flooring. Electrophysiological features of the neuropathy were loss in the amplitude of the distal tibial nerve M potential recorded over hind limb foot muscles, temporal dispersion of the potential, often into multiple peaks, and a prolonged distal latency of the response. The changes in M amplitude were more apparent in larger rats with a greater body weight. In a second series of experiments we studied sciatic-tibial conduction over 16 weeks in nondiabetic rats and rats rendered diabetic with streptozotocin raised and wire grid or plastic flooring. Tibial mononeuropathy developed in both wire grid-reared groups, but there was evidence that it appeared earlier in diabetic rats. Electrophysiological changes of distal mononeuropathy also obscured the expected slowing of sciatic-tibial motor conduction velocity from diabetics. Tibial mononeuropathy in rats reared on wire grid flooring may be a useful animal model of human entrapment neuropathy but its presence can confound studies of experimental neuropathy. Rats used in studies of experimental neuropathy should be housed in plastic cages with sawdust or shavings flooring.
我们利用电生理记录技术，研究了一种累及在带有金属丝网地板的笼中饲养的大鼠后足的胫神经远端单神经病。在最初的一组实验中，对饲养在带有金属丝网或锯末地板的笼中的大小不同的大鼠进行了坐骨-胫神经运动传导的系列记录。该神经病的电生理特征为：在后肢足部肌肉记录到的胫神经M波幅降低、电位的时间离散，常呈多个峰，以及反应的远端潜伏期延长。M波幅的变化在体重较大的大鼠中更为明显。在第二系列实验中，我们研究了非糖尿病大鼠以及用链脲佐菌素诱导糖尿病的大鼠在16周内饲养在带有金属丝网或塑料地板的笼中的坐骨-胫神经传导情况。在两个饲养在金属丝网地板笼中的组中均出现了胫神经单神经病，但有证据表明其在糖尿病大鼠中出现得更早。远端单神经病的电生理变化也掩盖了糖尿病大鼠坐骨-胫神经运动传导速度预期的减慢。饲养在金属丝网地板笼中的大鼠的胫神经单神经病可能是人类卡压性神经病的一种有用动物模型，但其存在可能会混淆实验性神经病的研究。用于实验性神经病研究的大鼠应饲养在铺有锯末或刨花的塑料笼中。
