Enzelsberger H, Eppel W, Dorninger G, Wewalka G
Univ.-Frauenklinik Wien.
Geburtshilfe Frauenheilkd. 1995 Dec;55(12):707-10. doi: 10.1055/s-2007-1022319.
In a prospective clinical study we investigated 115 patients prior to vaginal surgical interventions to determine the antimicrobial efficacy of six different procedures for vaginal antisepsis. To sample the microorganisms we used a cotton swab moistened with a neutralising fluid. Immediately after the time of action of the antiseptic procedures (3 minutes), providone-iodine solution, applied undiluted or diluted 1:10, yielded the strongest median reduction of the vaginal flora (log RF 3.60 and 2.68, respectively). Of three detergents with antiseptic efficacy, octenidine 0.1% was the most efficient formula (log RF 2.32). After 30 minutes the log reduction factors (log RF) of almost all procedures (log RF 2.79-3.25) were in a fairly close range, excepting chlorohexidine 0.05% (log RF 2.07). Overall, the antiseptic detergents showed a marked residual effect, which was less pronounced, if at all, with providone-iodine solutions. A germ-reducing effect of povidone-iodine vaginal suppositories, applied 2 to 3 hrs prior to surgery, was not confirmed, while additional findings indicated that providone-iodine solution applied with the help of a vaginal douche yields a similarly strong germ reduction as the application by means of a ball swabs.
在一项前瞻性临床研究中，我们对115例接受阴道手术干预的患者进行了调查，以确定六种不同阴道消毒程序的抗菌效果。为了采集微生物样本，我们使用了用中和液湿润的棉拭子。在消毒程序作用时间（3分钟）后立即进行检测，未稀释或1:10稀释的聚维酮碘溶液使阴道菌群的中位减少量最大（对数减少率分别为3.60和2.68）。在三种具有抗菌效果的洗涤剂中，0.1%奥替尼啶是最有效的配方（对数减少率为2.32）。30分钟后，几乎所有程序的对数减少因子（对数减少率）（对数减少率为2.79 - 3.25）都处于相当接近的范围内，除了0.05%氯己定（对数减少率为2.07）。总体而言，抗菌洗涤剂显示出明显的残留效应，而聚维酮碘溶液的残留效应则不太明显（如果有残留效应的话）。术前2至3小时使用聚维酮碘阴道栓剂的杀菌效果未得到证实，而其他研究结果表明，借助阴道冲洗器应用聚维酮碘溶液与通过棉球涂抹产生的杀菌效果相似。
