Dundore P A, Schwartz A M, Semerjian H
Department of Pathology, George Washington University Medical Center, Washington, D.C., USA.
J Urol. 1996 Mar;155(3):885-7.
Mast cell counts have been advocated as useful in the pathological diagnosis of interstitial cystitis. To determine the clinical significance of mucosal and detrusor muscle mast cells we quantified mast cells within the lamina propria and detrusor muscle in nonulcerative interstitial cystitis, and various inflammatory and neoplastic bladder diseases.
Mast cells from Giemsa stained sections were enumerated from 8 cases of clinically diagnosed nonulcerated interstitial cystitis and 32 control cases having inflammatory or neoplastic bladder disease. Cystectomy specimens from controls also included sections from normal (5) and inflamed transitional mucosa (4) distant from the invasive tumor.
There was no significant difference in mast cell counts when considered absolutely or relative to the muscle-to-mucosa ratio in cases of nonulcerative interstitial cystitis and controls.
Our findings indicate that mast cell counts are not useful in the evaluation of nonulcerative interstitial cystitis and do not represent a diagnostic criterion for inclusion or exclusion of the disease.
肥大细胞计数被认为对间质性膀胱炎的病理诊断有用。为了确定黏膜和逼尿肌肥大细胞的临床意义，我们对非溃疡性间质性膀胱炎以及各种炎性和肿瘤性膀胱疾病的固有层和逼尿肌中的肥大细胞进行了定量分析。
从8例临床诊断为非溃疡性间质性膀胱炎的病例以及32例患有炎性或肿瘤性膀胱疾病的对照病例中，对吉姆萨染色切片中的肥大细胞进行计数。对照的膀胱切除标本还包括来自远离浸润性肿瘤的正常（5例）和炎性移行黏膜（4例）的切片。
在非溃疡性间质性膀胱炎病例和对照中，无论是绝对计数还是相对于肌层与黏膜层比例的计数，肥大细胞数量均无显著差异。
我们的研究结果表明，肥大细胞计数在评估非溃疡性间质性膀胱炎时并无用处，也不代表该疾病纳入或排除的诊断标准。
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