多巴胺 D1 受体拮抗剂 SCH 23390 可对大鼠伏隔核神经元产生 D1 激动剂样效应。

The dopamine D1 receptor antagonist SCH 23390 can exert D1 agonist-like effects on rat nucleus accumbens neurons.

作者信息

Wachtel S R, White F J

机构信息

Department of Neurology, University of Chicago, IL 60637, USA.

出版信息

Neurosci Lett. 1995 Oct 13;199(1):13-6. doi: 10.1016/0304-3940(95)12025-y.

DOI:10.1016/0304-3940(95)12025-y

PMID:8584215

Abstract

Interactions between the selective dopamine D1-class receptor antagonist SCH 23390 and the dopamine D2-class receptor agonist quinpirole on nucleus accumbens neurons were investigated with extracellular single cell recording and microiontophoresis. Because dopamine D1 receptor stimulation enables many dopamine D2 receptor-mediated effects, SCH 23390 was expected to antagonize quinpirole-induced inhibition of activity. Although concurrent iontophoretic administration of SCH 23390 attenuated the inhibitory effects of quinpirole on most neurons, the antagonist further suppressed the firing of most neurons during attempts to reverse quinpirole-induced inhibition. SCH 23390 also reinstated (enabled) quinpirole-induced inhibition in rats acutely depleted of dopamine. These findings suggest that under certain conditions, SCH 23390 may exert dopamine D1 agonist-like effects.

摘要

采用细胞外单细胞记录和微离子电泳技术，研究了选择性多巴胺D1类受体拮抗剂SCH 23390与多巴胺D2类受体激动剂喹吡罗对伏隔核神经元的相互作用。由于多巴胺D1受体的刺激能够引发许多由多巴胺D2受体介导的效应，因此预计SCH 23390会拮抗喹吡罗诱导的活性抑制。尽管同时进行SCH 23390的离子电泳给药减弱了喹吡罗对大多数神经元的抑制作用，但在试图逆转喹吡罗诱导的抑制过程中，该拮抗剂进一步抑制了大多数神经元的放电。SCH 23390还恢复了（使能）急性多巴胺耗竭大鼠中喹吡罗诱导的抑制作用。这些发现表明，在某些条件下，SCH 23390可能发挥多巴胺D1激动剂样效应。