Lacombe M
Hôpital Beaujon, Clichy.
J Mal Vasc. 1995;20(4):257-63.
A retrospective study of the patients operated on for renal artery aneurysm by a single surgeon during a 30-year period was undertaken. The author's experience amounts to 123 patients of whom 74 were females (60%) and 49 males (40%). The average age of the patients was 42.8 years. Preoperative investigations included usual tests of renal function, radiological investigations (fig. 4 and 5) and especially renal arteriography and study of the repercussions of arterial hypertension when present. In most cases (90%) these aneurysms were of fibrodysplastic origin. Acquired or postoperative aneurysms accounted for only 10% of cases. Dysplastic aneurysms are usually saccular with a fibrous neck and are located at or near an arterial bifurcation (fig. 1); they may have a very thin wall that explains the possible occurrence of rupture; intrasaccular thrombosis is very rare and so are embolies in the kidneys. Associated lesions are present in about two thirds of the patients (table I) and require a complete evaluation before surgery: lesions of the renal artery (segmental stenosis or diffuse fibromuscular hyperplasia) are the most frequent (fig. 2 and 3); other arteries either in the abdomen (aorta, splenic) or in distant territories (carotid) may also exhibit pathologic changes, particularly aneurysms; lesions of the kidney(s) and/or of the urinary tract may also be observed. In 80% of patients, the aneurysms were discovered on angiography performed because of arterial hypertension. But 20% of the patients were strictly normotensive. On account of bilateral repairs, 128 operations were performed: 17 nephrectomies and 111 vascular reconstructions. The main indication for nephrectomy was severely damaged kidneys. Vascular repair is the ideal treatment and various techniques may be used depending on anatomical arrangement of the vessels (table II). Ex situ surgery was performed in 29% of patients. Use of an arterial substitute is optional; when it appears necessary, arterial autografts are always preferable because they do not undergo late degenerative changes with time. The morbidity of surgical treatment is low. Evolution of arterial blood pressure after surgery leads to think that aneurysms of the renal artery cannot be held responsible for arterial hypertension: whenever a stenosis of the renal artery is associated, hypertension is of renovascular origin and is constantly cured or improved after surgery; in other patients, arterial hypertension remains unchanged after repair of the aneurysm, suggesting that hypertension is essential and simply coexists with the aneurysm without relationships of cause and effect between them. Surgery prevents the occurrence of ruptures as well and gives long term satisfactory anatomical results (fig. 6). Surgery is indicated in most cases and especially in young women (because of the risk of rupture during pregnancy) and in aneurysms exceeding 2 cm in diameter.
对一位外科医生在30年期间为肾动脉动脉瘤患者实施手术的情况进行了回顾性研究。作者的经验涉及123例患者,其中74例为女性(60%),49例为男性(40%)。患者的平均年龄为42.8岁。术前检查包括常规的肾功能检查、放射学检查(图4和图5),尤其包括肾动脉造影以及对存在动脉高血压时的影响进行研究。在大多数病例(90%)中,这些动脉瘤起源于纤维发育异常。后天性或术后动脉瘤仅占病例的10%。发育异常性动脉瘤通常为囊状,有纤维性颈部,位于动脉分叉处或其附近(图1);它们的壁可能非常薄,这解释了可能发生破裂的原因;囊内血栓形成非常罕见,肾内栓塞也很少见。约三分之二的患者存在相关病变(表I),手术前需要进行全面评估:肾动脉病变(节段性狭窄或弥漫性纤维肌增生)最为常见(图2和图3);腹部的其他动脉(主动脉、脾动脉)或远处区域的动脉(颈动脉)也可能出现病理改变,尤其是动脉瘤;肾脏和/或尿路的病变也可能被观察到。80%的患者是在因动脉高血压进行血管造影时发现动脉瘤的。但20%的患者血压完全正常。由于进行了双侧修复,共实施了128次手术:17例肾切除术和111例血管重建术。肾切除术的主要指征是肾脏严重受损。血管修复是理想的治疗方法,可根据血管的解剖结构采用各种技术(表II)。29%的患者进行了体外手术。是否使用动脉替代物可酌情决定;当有必要时,自体动脉移植总是更可取的,因为它们不会随着时间的推移发生晚期退行性改变。手术治疗的发病率较低。手术后动脉血压的变化使人认为肾动脉动脉瘤并非动脉高血压的病因:只要伴有肾动脉狭窄,高血压就是肾血管性的,手术后通常会治愈或改善;在其他患者中,动脉瘤修复后动脉高血压保持不变,这表明高血压是原发性的,只是与动脉瘤并存,它们之间没有因果关系。手术还可预防破裂的发生,并能长期提供令人满意的解剖学效果(图6)。大多数情况下都应进行手术,尤其是年轻女性(因为怀孕时有破裂风险)以及直径超过2厘米的动脉瘤。