Bohuslavizki K H, Oberwöhrmann S, Brenner W, Eberhardt J U, Mönig H, Clausen M, Sippel C, Wolf H, Epe B, Henze E
Clinic of Nuclear Medicine, Christian-Albrechts-Universität Kiel, Germany.
Nucl Med Commun. 1995 Nov;16(11):912-6. doi: 10.1097/00006231-199511000-00006.
The aim of this study was to examine patients with long-standing Graves' ophthalmopathy using 111In-octreotide scintigraphy. Sixteen patients with inactive ophthalmopathy of up to 114 months duration and 14 normals were investigated for 48 h following an injection of 200 MBq 111In-octreotide. No significant tracer accumulation in the orbital region could be identified in any of the patients with long-standing Graves' ophthalmopathy. The orbit to brain (O/B) ratios after 24 and 48 h were 2.39 +/- 0.36 and 2.15 +/- 0.44 versus 2.17 +/- 0.33 and 2.20 +/- 0.37 for the patients and normals, respectively (N.S.). 111In-octreotide accumulation in ophthalmopathy described in the literature may thus be a passing event limited to its active stage, which is consistent with the concept of imaging a lymphocytic infiltration. In this study, the lack of accumulation of 111In-octreotide in the orbital region during the inactive stage demonstrates an absence of somatostatin receptors in orbital tissue itself. Thus, in patients with inactive Graves' ophthalmopathy, there is no basis for a diagnostic approach with somatostatin.
本研究的目的是使用111铟-奥曲肽闪烁扫描术检查患有长期格雷夫斯眼病的患者。对16例非活动性眼病病程长达114个月的患者和14名正常人注射200MBq的111铟-奥曲肽后进行48小时的研究。在任何患有长期格雷夫斯眼病的患者中均未发现眼眶区域有明显的示踪剂聚集。患者组和正常组在24小时和48小时后的眶脑（O/B）比值分别为2.39±0.36和2.15±0.44，以及2.17±0.33和2.20±0.37（无显著性差异）。因此，文献中描述的奥曲肽在眼病中的聚集可能是仅限于其活动期的一个短暂现象，这与淋巴细胞浸润成像的概念一致。在本研究中，非活动期眼眶区域缺乏111铟-奥曲肽的聚集表明眼眶组织本身不存在生长抑素受体。因此，对于非活动性格雷夫斯眼病患者，没有使用生长抑素进行诊断的依据。
