一种合成孕激素R5020与皮质素转运蛋白及血清白蛋白的结合。
The binding of a synthetic progestin, R5020 to transcortin and serum albumin.
作者信息
Chan D W, Slaunwhite W R
出版信息
J Clin Endocrinol Metab. 1977 May;44(5):983-5. doi: 10.1210/jcem-44-5-983.
PMID:858781
Abstract
R5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass = 8 X 10(6)M-1); in 20% human serum or albumin greater than 90% was bound with low Kass and an indeterminate number of binding sites.
摘要
R5020（17,21 - 二甲基 - 19 - 去甲 - 4,9 - 孕二烯 - 3,20 - 二酮），一种合成孕激素，被测试其与纯化的人皮质类固醇结合球蛋白、白蛋白及人血清的结合情况。斯卡查德分析表明，R5020与皮质类固醇结合球蛋白的结合相对较弱（结合常数Kass = 8×10⁶M⁻¹）；在20%的人血清或白蛋白中，超过90%以低结合常数和不确定数量的结合位点结合。
Zotero 插件