Vartiainen E, Karjalainen S, Nuutinen J, Suntioinen S, Pellinen P
Department of Otolaryngology, University of Kuopio, Finland.
Am J Otol. 1994 Jul;15(4):545-8.
Fluorine content in bone samples taken from the middle ears of otosclerotic patients was determined. Otosclerotic stapes footplate was found to have a significantly higher content of fluorine than skeletal bone from the meatus. Fluorine contents in footplate and meatal wall samples of otosclerotic patients drinking fluoridated water were slightly higher than those of patients drinking low-fluoride water. In the clinical part of the study, hearing levels of 280 patients with otosclerosis living in an area with low-fluoride water were assessed. In 344 operated ears, the preoperative and long-term postoperative air conduction and bone conduction thresholds of patients drinking fluoridated water did not differ significantly from those of patients drinking low-fluoride water. After a mean follow-up period of 9.6 years, air conduction thresholds of non-operated ears in patients drinking fluoride-poor water were found to be significantly worse than those of patients drinking fluoridated tap water, likewise there were significant differences in bone conduction thresholds at 2 and 4 kHz. Thus, fluoridation of drinking water has a beneficial effect on non-operated otosclerotic ears but has no significant effect on hearing levels of operated ears.
测定了取自耳硬化症患者中耳的骨样本中的氟含量。发现耳硬化症镫骨足板的氟含量明显高于耳道骨骼。饮用含氟水的耳硬化症患者足板和耳道壁样本中的氟含量略高于饮用低氟水的患者。在该研究的临床部分，评估了生活在低氟水地区的280例耳硬化症患者的听力水平。在344只接受手术的耳朵中，饮用含氟水的患者术前和长期术后气导和骨导阈值与饮用低氟水的患者相比无显著差异。平均随访9.6年后，发现饮用低氟水的患者未手术耳朵的气导阈值明显差于饮用含氟自来水的患者，同样在2kHz和4kHz的骨导阈值也存在显著差异。因此，饮用水加氟对未手术的耳硬化症耳朵有有益影响，但对接受手术耳朵的听力水平无显著影响。
