通过强化牛奶增加冬季维生素D和钙摄入量的安全性和有效性。

Safety and efficacy of increasing wintertime vitamin D and calcium intake by milk fortification.

作者信息

McKenna M J, Freaney R, Byrne P, McBrinn Y, Murray B, Kelly M, Donne B, O'Brien M

机构信息

Metabolism Laboratory, St Vincent's Hospital, Dublin, Ireland.

出版信息

QJM. 1995 Dec;88(12):895-8.

PMID:8593549

Abstract

We studied the safety and efficacy of milk fortified with vitamin D3 and calcium. Over the winter, we conducted a double-blind, placebo-controlled trial of fortified milk (12 micrograms vitamin D3 and 1525 mg calcium per litre) compared to unfortified milk (0.3 micrograms vitamin D3 and 1270 mg calcium per litre) in 102 adults (aged 17-54 years). Serum 25-hydroxyvitamin D [25(OH)D], ionized calcium, and creatinine were measured at baseline and after intervention. Fortification reduced the seasonal decline in serum 25(OH)D concentrations by > 50%. In the fortified group, serum 25(OH)D decreased by 15 nmol/l from 77 +/- 35 nmol/l to 62 +/- 26 nmol/l (p < 0.001). In the control group, serum 25(OH)D fell by 31 nmol/l from 85 +/- 38 nmol/l to 54 +/- 25 nmol/l (p < 0.001). We suggest that milk enriched with vitamin D be provided in high-latitude European countries to diminish the wintertime fall in serum 25(OH)D.

摘要

我们研究了添加维生素D3和钙的牛奶的安全性和功效。在冬季，我们对102名成年人（年龄在17 - 54岁之间）进行了一项双盲、安慰剂对照试验，比较了强化牛奶（每升含12微克维生素D3和1525毫克钙）与未强化牛奶（每升含0.3微克维生素D3和1270毫克钙）。在基线和干预后测量血清25 - 羟基维生素D [25(OH)D]、离子钙和肌酐。强化措施使血清25(OH)D浓度的季节性下降减少了50%以上。在强化组中，血清25(OH)D从77±35纳摩尔/升降至62±26纳摩尔/升，下降了15纳摩尔/升（p < 0.001）。在对照组中，血清25(OH)D从85±38纳摩尔/升降至54±25纳摩尔/升，下降了31纳摩尔/升（p < 0.001）。我们建议在高纬度欧洲国家提供富含维生素D的牛奶，以减少冬季血清25(OH)D的下降。