Hashimoto-Uoshima M, Ishikawa I, Kinoshita A, Weng H T, Oda S
Department of Periodontology, Tokyo Medical and Dental University, Faculty of Dentistry, Japan.
Int J Periodontics Restorative Dent. 1995 Apr;15(2):205-13.
Biphasic calcium phosphate, consisting of beta-tricalcium phosphate and hydroxyapatite, was implanted in wide and deep periodontal osseous defects of monkeys in combination with the guided tissue regeneration technique. After 12 weeks, sites treated with a combination of biphasic calcium phosphate and guided tissue regeneration maintained the shape of the ridge, but both guided tissue regeneration and control sites (untreated) showed extreme resorption. A histopathologic investigation revealed that numerous macrophages contained small particles of ceramic within their vesicles and the active bone replacement occurred from the surrounding bone. Biphasic calcium phosphate has osteoconductive potential and this potential may be related to degradation by macrophage phagocytosis.
由β-磷酸三钙和羟基磷灰石组成的双相磷酸钙，与引导组织再生技术相结合，植入猴子广泛而深的牙周骨缺损处。12周后，双相磷酸钙与引导组织再生联合治疗的部位保持了牙槽嵴的形状，但引导组织再生部位和对照部位（未治疗）均出现了严重吸收。组织病理学研究显示，许多巨噬细胞的囊泡内含有陶瓷小颗粒，活性骨替代从周围骨发生。双相磷酸钙具有骨传导潜力，这种潜力可能与巨噬细胞吞噬作用导致的降解有关。
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