Beneficial effects of pentoxifylline in neonatal rats infected with group B streptococci. - Suppr | 超能文献

Beneficial effects of pentoxifylline in neonatal rats infected with group B streptococci.

作者信息

Mancuso G, Blandino G, Gambuzza M, Genovese F, Migliardo M, Carbone M, Fera M T, Cusumano V

机构信息

Institute of Microbiology, University of Messina, Italy.

出版信息

J Chemother. 1995 Oct;7(5):417-9. doi: 10.1179/joc.1995.7.5.417.

DOI:10.1179/joc.1995.7.5.417

Abstract

Previous studies have indicated that tumor necrosis factor-alpha (TNF-alpha) may play a pathophysiologic role in experimental sepsis by group B streptococci (GBS). We tested the efficacy of some TNF-alpha and eicosanoid inhibitors in a neonatal rat model of GBS disease. The drugs tested included cloricromene, SKF86002, pentoxifylline, CGS8515, ibuprofen and LY203647. None of these compounds were protective against GBS infection, with the exception of pentoxifylline, that produced a moderate enhancement of survival time. Further studies are needed to ascertain if specific inhibitors of TNF-alpha, alone or in conjunction with antibiotics, may be effective as therapeutic agents in neonatal GBS sepsis.

摘要

相似文献

1

Beneficial effects of pentoxifylline in neonatal rats infected with group B streptococci.

J Chemother. 1995 Oct;7(5):417-9. doi: 10.1179/joc.1995.7.5.417.

2

Efficacy of tumor necrosis factor alpha and eicosanoid inhibitors in experimental models of neonatal sepsis.

FEMS Immunol Med Microbiol. 1994 Jun;9(1):49-54. doi: 10.1111/j.1574-695X.1994.tb00473.x.

3

Antibodies to tumor necrosis factor-alpha: use as adjunctive therapy in established group B streptococcal disease in newborn rats.

Pediatr Res. 1995 Oct;38(4):551-4. doi: 10.1203/00006450-199510000-00013.

4

Group B streptococcus induces tumor necrosis factor in neonatal piglets. Effect of the tumor necrosis factor inhibitor pentoxifylline on hemodynamics and gas exchange.

Am Rev Respir Dis. 1991 Mar;143(3):598-604. doi: 10.1164/ajrccm/143.3.598.

5

Group B streptococcal sepsis in piglets: effect of combined pentoxifylline and indomethacin pretreatment.

Pediatr Res. 1992 Mar;31(3):222-7. doi: 10.1203/00006450-199203000-00006.

6

Induction of tumor necrosis factor alpha by the group- and type-specific polysaccharides from type III group B streptococci.

Infect Immun. 1994 Jul;62(7):2748-53. doi: 10.1128/iai.62.7.2748-2753.1994.

7

Effects of pentoxifylline on in vivo leukocyte function and clearance of group B streptococci from preterm rabbit lungs.

Crit Care Med. 1993 May;21(5):712-20. doi: 10.1097/00003246-199305000-00015.

8

Effects of treatment with pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet.

Pediatr Res. 1996 Sep;40(3):469-74. doi: 10.1203/00006450-199609000-00017.

9

Prophylactic or simultaneous administration of recombinant human granulocyte colony stimulating factor in the treatment of group B streptococcal sepsis in neonatal rats.

Pediatr Res. 1990 Jun;27(6):612-6. doi: 10.1203/00006450-199006000-00016.

10

Production of tumor necrosis factor-alpha and interleukin-6 in mice infected with group B streptococci.

Circ Shock. 1992 Oct;38(2):138-44.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。