Forsthuber T, Yip H C, Lehmann P V
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-4943, USA.
Science. 1996 Mar 22;271(5256):1728-30. doi: 10.1126/science.271.5256.1728.
The neonatal period has been thought of as a window in ontogeny, during which the developing immune system is particularly susceptible to tolerization. In the present study, the classic system for induction of neonatal tolerance to protein antigens was reexamined in mice. The presumably tolerogenic protocol was found to trigger a vigorous T helper cell type 2 (TH2) immune response. Thus, neonatal "tolerization" induces immune deviation, not tolerance in the immunological sense. Neonates are not immune privileged but generate TH2 or TH1 responses, depending on the mode of immunization.
新生儿期一直被认为是个体发育过程中的一个窗口，在此期间，发育中的免疫系统特别容易受到免疫耐受的影响。在本研究中，我们在小鼠身上重新审视了诱导新生儿对蛋白质抗原产生耐受的经典系统。结果发现，推测具有致耐受性的方案会引发强烈的2型辅助性T细胞（TH2）免疫反应。因此，新生儿“耐受诱导”会导致免疫偏离，而非免疫意义上的耐受。新生儿并非免疫特权群体，而是根据免疫方式产生TH2或TH1反应。
