Naimark D, Jackson E, Rockwell E, Jeste D V
Geriatric Psychiatry Clinical Research Center, University of California, San Diego, USA.
J Am Geriatr Soc. 1996 Mar;44(3):296-9. doi: 10.1111/j.1532-5415.1996.tb00918.x.
To assess the prevalence of psychotic symptoms in a group of patients with Parkinson's disease (PD) and dementia and examine the association of psychotic symptoms with neuropsychiatric problems, the level of distress reported by caregivers, and cognitive and functional impairment.
The psychotic and nonpsychotic patients with PD dementia were compared on a series of demographic, neuropsychiatric, behavioral, caregiver complaint, and cognitive measures.
The database from nine university-based State of California Alzheimer's Disease Diagnostic and Treatment Centers (ADDTCs).
101 patients diagnosed with PD.
A total of 36 of the 101 patients (35.6%) had either hallucinations, delusions, or both. The psychotic patients had significantly more insomnia, confusion, agitation, personality changes, and self-care problems and were noted by their caregivers to be significantly more unmanageable at home than their nonpsychotic counterparts. On cognitive scales, psychotic patients were significantly more impaired.
Many patients with PD and dementia experience psychosis. Psychotic symptoms in PD dementia patients are associated with major behavioral, cognitive, and functional problems.
评估一组帕金森病（PD）合并痴呆患者的精神病性症状患病率，并研究精神病性症状与神经精神问题、照料者报告的痛苦程度以及认知和功能损害之间的关联。
对患有PD痴呆的精神病性和非精神病性患者在一系列人口统计学、神经精神、行为、照料者抱怨及认知指标方面进行比较。
来自加利福尼亚州九所大学附属阿尔茨海默病诊断与治疗中心（ADDTCs）的数据库。
101名被诊断为PD的患者。
101名患者中共有36名（35.6%）出现幻觉、妄想或两者皆有。与非精神病性患者相比，精神病性患者有更多的失眠、意识模糊、激越、人格改变和自我照料问题，且照料者指出他们在家中明显更难管理。在认知量表上，精神病性患者受损更严重。
许多PD合并痴呆患者会出现精神病症状。PD痴呆患者的精神病性症状与主要的行为、认知和功能问题相关。
