Aldous M B, Holberg C J, Wright A L, Martinez F D, Taussig L M
Department of Pediatrics, University of Arizona College of Medicine, Tucson, USA.
Am J Epidemiol. 1996 Mar 1;143(5):423-30. doi: 10.1093/oxfordjournals.aje.a008762.
Lower respiratory tract illness (LRI) is associated with exposure to various environmental factors. The relation between home environment and LRI in infants was studied with the use of data from the Children's Respiratory Study in Tucson, Arizona. Healthy infants from a health maintenance organization were recruited at birth (1980-1984). Analysis was restricted to one infant per family, and to those followed through the first year (n=936). Environmental data were collected at enrollment, and clinicians diagnosed LRI according to predetermined criteria. During the first year of life, 196 infants (21%) had wheezing LRI, and 60 (6%) had nonwheezing LRI. The risk of wheezing LRI was higher in infants with evaporative home cooling (24%) than in those without evaporative home cooling (15%) (odds ratio = 1.8, 95% confidence interval 1.1-3.0); this association was stronger among infants who lived with other children in the home. The risk of nonwheezing LRI was associated with parents' rating of neighborhood dustiness, ranging from 5% in the least dusty environments to 12% in the dustiest (p for trend = 0.002). Neither association could be explained by confounding factors. LRI was not related to the type of home heating, cooking fuel, or the numbers of indoor dogs or cats.
下呼吸道疾病(LRI)与接触各种环境因素有关。利用亚利桑那州图森市儿童呼吸研究的数据,对婴儿家庭环境与LRI之间的关系进行了研究。从一个健康维护组织招募了出生时(1980 - 1984年)的健康婴儿。分析仅限于每个家庭一名婴儿,以及那些随访至一岁的婴儿(n = 936)。在入组时收集环境数据,临床医生根据预定标准诊断LRI。在生命的第一年,196名婴儿(21%)患有喘息性LRI,60名(6%)患有非喘息性LRI。采用家庭蒸发冷却的婴儿患喘息性LRI的风险(24%)高于未采用家庭蒸发冷却的婴儿(15%)(优势比 = 1.8,95%置信区间1.1 - 3.0);这种关联在与家中其他儿童一起生活的婴儿中更强。非喘息性LRI的风险与父母对邻里灰尘程度的评分有关,在灰尘最少的环境中为5%,在灰尘最多的环境中为12%(趋势p值 = 0.002)。这两种关联都无法用混杂因素来解释。LRI与家庭供暖类型(21%)、烹饪燃料类型(21%)或室内狗或猫的数量无关。