Di Lazzaro V, Restuccia D, Nardone R, Tartaglione T, Quartarone A, Tonali P, Rothwell J C
Istituto di Neurologia, Università Cattolica, Rome, Italy.
Neurology. 1996 Feb;46(2):479-85. doi: 10.1212/wnl.46.2.479.
Short latency trigemino-cervical reflexes can be recorded from sternocleidomastoid muscle after stimulation of the infraorbital branch of the trigeminal nerve. We studied the trigemino-cervical reflexes and the conventional blink reflex in three patients with an isolated lesion in the medulla oblongata, eight patients with multiple sclerosis, and two patients with supratentorial ischemic lesion. The trigemino-cervical response was abnormal in the patients with an isolated lesion in the medulla oblongata and in all multiple sclerosis patients, whereas both components of the blink reflex were preserved in the patients with a lesion in the medulla oblongata and in half of the patients with multiple sclerosis. The trigemino-cervical reflex was preserved in patients with supratentorial lesions, whereas the late component of the blink reflex was abnormal. These findings suggest that central pathways generating the trigemino-cervical reflex are confined to the medulla oblongata and that they are independent from those generating the long latency (R2) component of the blink reflex. The trigemino-cervical reflex may help in disclosing and localizing brainstem lesions.
刺激三叉神经眶下支后，可从胸锁乳突肌记录到短潜伏期三叉神经 - 颈反射。我们研究了3例延髓孤立性病变患者、8例多发性硬化症患者和2例幕上缺血性病变患者的三叉神经 - 颈反射及传统眨眼反射。延髓孤立性病变患者及所有多发性硬化症患者的三叉神经 - 颈反射均异常，而延髓病变患者及半数多发性硬化症患者的眨眼反射两个成分均保留。幕上病变患者的三叉神经 - 颈反射保留，而眨眼反射的晚期成分异常。这些发现表明，产生三叉神经 - 颈反射的中枢通路局限于延髓，且它们独立于产生眨眼反射长潜伏期（R2）成分的通路。三叉神经 - 颈反射可能有助于发现和定位脑干病变。
