一种与葡萄球菌α毒素和蛋白A相互作用的人IgA骨髓瘤蛋白。
A human IgA myeloma protein interacting with staphylococcal alpha-toxin and protein A.
作者信息
Dalen A, Grov A, Matre R, Myking O L
出版信息
Clin Exp Immunol. 1977 Mar;27(3):421-4.
Abstract
High anti-staphylolysin activity was found in the serum from a patient with multiple myeloma. The activity was confined to the monoclonal IgA protein and was dependent on an intact Fc part of the molecule. An Fc-dependent interaction with protein A was also demonstrated. In addition, a part of the monoclonal IgA was found to be complexed with alpha2-macroglobulin. The results imply an unusual Fc-reactivity of the IgA protein.
摘要
在一名多发性骨髓瘤患者的血清中发现了高抗葡萄球菌溶血素活性。该活性局限于单克隆IgA蛋白，并且依赖于分子完整的Fc部分。还证实了与蛋白A的Fc依赖性相互作用。此外，发现一部分单克隆IgA与α2-巨球蛋白复合。结果表明IgA蛋白具有异常的Fc反应性。
相似文献
1
A human IgA myeloma protein interacting with staphylococcal alpha-toxin and protein A.一种与葡萄球菌α毒素和蛋白A相互作用的人IgA骨髓瘤蛋白。
Clin Exp Immunol. 1977 Mar;27(3):421-4.
2
Human myeloma IgA half-molecules.人骨髓瘤IgA半分子
J Clin Invest. 1976 Nov;58(5):1259-65. doi: 10.1172/JCI108580.
3
A human IgG myeloma protein with anti- 2 macroglobulin antibody activity.一种具有抗2巨球蛋白抗体活性的人IgG骨髓瘤蛋白。
J Immunol. 1973 Jan;110(1):85-90.
4
Acute phase reactants and clinical stages in multiple myeloma.多发性骨髓瘤中的急性期反应物与临床分期
Neoplasma. 1981;28(3):333-8.
5
Differential susceptibility of human IgA immunoglobulins to streptococcal IgA protease.人IgA免疫球蛋白对链球菌IgA蛋白酶的敏感性差异
J Clin Invest. 1974 Dec;54(6):1295-300. doi: 10.1172/JCI107875.
6
Spontaneous expression of a low affinity Fc receptor for IgA (Fc alpha R) on human B cell lines.人B细胞系上IgA低亲和力Fc受体（FcαR）的自发表达。
Clin Exp Immunol. 1989 May;76(2):268-73.
7
Influence of the alternative protein A interaction on the precipitation between human monoclonal immunoglobulins and protein A from Staphylococcus aureus.替代蛋白A相互作用对人单克隆免疫球蛋白与金黄色葡萄球菌蛋白A之间沉淀反应的影响。
Int Arch Allergy Appl Immunol. 1981;65(1):91-101. doi: 10.1159/000232743.
8
9
[Tumor-forming type IgA (kappa) multiple myeloma developed into polyclonal hyper gamma-globulinemia after M-protein loss].
Rinsho Ketsueki. 1991 Sep;32(9):964-9.
10
Receptors for IgA on rabbit lymphocytes. II. Characterization of their binding parameters for IgA.兔淋巴细胞上的IgA受体。II. 其与IgA结合参数的特征
J Immunol. 1982 May;128(5):2201-5.
引用本文的文献
1
B cell superantigens: a microbe's answer to innate-like B cells and natural antibodies.B细胞超抗原：微生物对固有样B细胞和天然抗体的应对方式
Springer Semin Immunopathol. 2005 Mar;26(4):463-84. doi: 10.1007/s00281-004-0190-2.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Extremely high content of anti-alpha-staphylolysin in serum samples from a patient with multiple myeloma.一名多发性骨髓瘤患者血清样本中抗α-葡萄球菌溶血素含量极高。
Acta Pathol Microbiol Scand. 1965;65(2):303-10. doi: 10.1111/apm.1965.65.2.303.
3
Plasmacytosis, probably of hereditary nature, with hyperglobulinaemia, sideropenia and elevated erythrocyte sedimentation rate in a child.
Scand J Infect Dis. 1971;3(2):177-81. doi: 10.3109/inf.1971.3.issue-2.14.
4
Recognition of two distinct groups of human IgM and IgA based on different binding to staphylococci.基于与葡萄球菌的不同结合识别出两类不同的人IgM和IgA。
Scand J Immunol. 1974;3(4):471-82. doi: 10.1111/j.1365-3083.1974.tb01280.x.
5
Antibody activity of human myeloma globulins.人骨髓瘤球蛋白的抗体活性
Semin Hematol. 1973 Apr;10(2):163-77.
6
The star phenomenon, a three component immunoprecipitation involving protein A.星状现象，一种涉及蛋白A的三元免疫沉淀反应。
Immunochemistry. 1971 Jun;8(6):577-80. doi: 10.1016/0019-2791(71)90412-5.
7
A simple procedure for the purification of staphylococcal alpha-toxin.一种纯化葡萄球菌α毒素的简单方法。
Acta Pathol Microbiol Scand B. 1976 Dec;84B(6):326-32. doi: 10.1111/j.1699-0463.1976.tb01948.x.
Zotero 插件