非氨酯相关的致死性急性肝坏死。

Felbamate-associated fatal acute hepatic necrosis.

作者信息

O'Neil M G, Perdun C S, Wilson M B, McGown S T, Patel S

机构信息

Department of Pharmacy Practice, College of Medicine, Medical University of South Carolina, Charleston, USA.

出版信息

Neurology. 1996 May;46(5):1457-9. doi: 10.1212/wnl.46.5.1457.

DOI:10.1212/wnl.46.5.1457

PMID:8628501

Abstract

Thirty-six cases of hepatic toxicity associated with felbamate therapy have been collected by the Food and Drug Administration. Five patients died. We describe a case of massive acute hepatic necrosis and death within 40 days of initiation of felbamate therapy for a generalized tonic-clonic seizure disorder. We describe the clinical and histopathologic features.

摘要

美国食品药品监督管理局已收集到36例与非氨酯治疗相关的肝毒性病例。其中5名患者死亡。我们描述了1例在开始使用非氨酯治疗全身性强直阵挛性癫痫障碍后40天内发生大规模急性肝坏死并死亡的病例。我们描述了其临床和组织病理学特征。