加州海兔ADP-核糖基环化酶的结晶
Crystallization of ADP-ribosyl cyclase from Aplysia californica.
作者信息
Pradas G S, Levitt D G, Lee H C, Stout C D
机构信息
Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
Proteins. 1996 Jan;24(1):138-40. doi: 10.1002/(SICI)1097-0134(199601)24:1<138::AID-PROT10>3.0.CO;2-P.
Abstract
ADP-ribosyl cyclase synthesizes the secondary messenger cyclic ADP-ribose from NAD+. Diffraction quality crystals of the enzyme from ovotestes of Aplysia californica have been obtained. Crystallographic analysis of this enzyme will yield insight into the mode of binding of the novel cyclic nucleotide and the mechanism by which NAD+ is cyclized.
摘要
ADP-核糖基环化酶从NAD⁺合成第二信使环ADP-核糖。已获得来自加州海兔卵睾体的该酶的衍射质量晶体。对这种酶进行晶体学分析将有助于深入了解这种新型环核苷酸的结合模式以及NAD⁺环化的机制。
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