Sutcliffe J R, Wilson-Storey D, Smith N M
Department of Paediatric Surgery, Royal Hospital for Sick Children, Edinburgh.
J R Coll Surg Edinb. 1996 Apr;41(2):99-101.
It has been suggested that the most likely cause of the Testicular Regression Syndrome (TRS) is ante-natal torsion of the testis. As testicular torsion is twice as common on the left this theory cannot explain the incidence of right sided or bilateral cases. From a 5-year retrospective surgical and pathological review, we confirmed that the left testis was the most commonly affected, that boys with TRS tended to be delivered closer to term, and that frequently both testes were present at birth, but one or both subsequently vanished. We also found that direct trauma can produce histological findings indistinguishable from TRS. Close to term, fetal testes are liable to be intrascrotal and therefore susceptible to direct trauma. As the left testis descends into the scrotum at an earlier stage than the right, it is therefore at greater risk of injury. Since the findings of TRS can be produced by direct trauma, we suggest that intra-partum trauma may predispose to the TRS.
有人提出，睾丸退化综合征（TRS）最可能的原因是产前睾丸扭转。由于睾丸扭转在左侧的发生率是右侧的两倍，该理论无法解释右侧或双侧病例的发生率。通过对5年的手术和病理回顾，我们证实左侧睾丸是最常受影响的，患有TRS的男孩往往在接近足月时出生，并且出生时通常两个睾丸都存在，但随后一个或两个睾丸消失了。我们还发现，直接创伤可产生与TRS难以区分的组织学表现。接近足月时，胎儿睾丸容易位于阴囊内，因此易受直接创伤。由于左侧睾丸比右侧睾丸更早下降到阴囊中，因此受伤风险更大。由于TRS的表现可由直接创伤引起，我们认为产时创伤可能易导致TRS。
