利多卡因与过渡金属络合物对大鼠肥大细胞组胺释放的影响。

Effect of complexes of lidocaine with transient metals on histamine release from rat mast cells.

作者信息

Kazimierczak W, Bańkowska K, Adamas B, Lewa A, Maśliński C

出版信息

Arch Immunol Ther Exp (Warsz). 1978;26(1-6):695-700.

Abstract

The effect of complexes of lidocaine with zinc, copper and cobalt on histamine release from peritoneal rat mast cells induced by various secretagogues was investigated. The complexes of lidocaine with metal ions inhibited histamine release induced by compound 48/80 and ionophoreous antibiotics: A23187 and X537A. The ionic complex of lidocaine with zinc was found to be the most potent against 48/80--induced histamine release and exerted the significant inhibition in the concentration of 10(-5) M. The action of coordination complex of lidocaine with zinc was somewhat weaker. The significant inhibitory effect on 48/80-induced histamine release of the copper and cobalt lidocaine complexes was observed in concentration of 10(-4) M. Histamine release by ionophores A23187 and X537A was also affected by zinc lidocaine complexes. However, coordination complex had more potent action on histamine release than the ionic one.

摘要

研究了利多卡因与锌、铜和钴的络合物对不同促分泌剂诱导的大鼠腹腔肥大细胞组胺释放的影响。利多卡因与金属离子的络合物抑制了由化合物48/80和离子载体抗生素A23187及X537A诱导的组胺释放。发现利多卡因与锌的离子络合物对48/80诱导的组胺释放作用最强，在10⁻⁵ M浓度时产生显著抑制。利多卡因与锌的配位络合物作用稍弱。在10⁻⁴ M浓度时观察到铜和钴利多卡因络合物对48/80诱导的组胺释放有显著抑制作用。离子载体A23187和X537A诱导的组胺释放也受锌利多卡因络合物影响。然而，配位络合物对组胺释放的作用比离子络合物更强。