Usui N, Yamauchi Y, Minoda H, Matsuura G, Goto H, Sakai J, Usui M, Yoshida S, Suzuki T, Tateyama M, Fukutake K
Department of Ophthalmology, Tokyo Medical College, Japan.
Nippon Ganka Gakkai Zasshi. 1996 Jan;100(1):84-92.
A case of Pneumocystis carinii (P. carinii) choroidopathy is reported. The patient was a 17-year-old man with acquired immunodeficiency syndrome (AIDS) who developed bilateral, multifocal, yellow-white, round, flat choroidal lesions ranging in size from 1/8 to 1/6 of the disc diameter while undergoing treatment for cytomegalovirus retinitis. He had had P. carinii pneumonia 43 months previously, and received inhaled pentamidine as suppressive therapy. Over a 4-week period of observation, the choroidal lesions appeared to enlarge slowly and increased in number in the posterior pole, with no clinical evidence of intraocular inflammation and retinal involvement. He was diagnosed as having P. carinii choroidopathy and treated with intravenous pentamidine. Three months after systemic pentamidine therapy was begun the choroidal lesions disappeared. Despite the fact that P. carinii choroidopathy is a rare opportunistic ocular infection, ophthalmic manifestations may be an important initial marker of extrapulmonary disseminated infection in some patients. Therefore we recommend ophthalmologic examinations in patients with AIDS who receive long-term aerosolized pentamidine prophylaxis for pneumonia.
报告了一例卡氏肺孢子虫脉络膜病变。患者为一名17岁患获得性免疫缺陷综合征(艾滋病)的男性,在接受巨细胞病毒性视网膜炎治疗期间,双眼出现多发、黄白色、圆形、扁平的脉络膜病变,大小从视盘直径的1/8至1/6不等。他43个月前曾患卡氏肺孢子虫肺炎,并接受吸入戊烷脒作为抑制性治疗。在为期4周的观察期内,脉络膜病变似乎缓慢扩大,后极部病变数量增加,无眼内炎症和视网膜受累的临床证据。他被诊断为患有卡氏肺孢子虫脉络膜病变,并接受静脉注射戊烷脒治疗。全身应用戊烷脒治疗开始3个月后,脉络膜病变消失。尽管卡氏肺孢子虫脉络膜病变是一种罕见的机会性眼部感染,但在某些患者中,眼部表现可能是肺外播散性感染的重要初始标志。因此,我们建议对接受长期雾化戊烷脒预防肺炎的艾滋病患者进行眼科检查。