[-内源性阿片类物质对下丘脑性闭经女性肾上腺皮质活动的影响-]
[-Effect of endogenous opioids on adrenal cortex activity in women with hypothalamic amenorrhea-].
作者信息
Krause B T, Möller S
机构信息
Klinik für Frauenheilkunde und Geburstshilfe, Medizinischen Fakultät, Ernst-Moritz-Arndt-Universität, Greifswald, Deutschland.
出版信息
Gynakol Geburtshilfliche Rundsch. 1995;35(4):194-8. doi: 10.1159/000272521.
OBJECTIVE
Within an ovulation induction study, we investigated the activity and reactivity of the hypothalamic-pituitary-adrenal axis in women suffering from hypothalamic amenorrhea by using naloxone.
METHODS
The central opioid receptors were blocked by means of a naloxone bolus injection of 4 mg i.v. daily.
RESULTS
Before and after receptor blockade, the cortisol secretion showed diverse results independently from the hypothalamic opioid tone. The cortisol levels were not elevated. Also, the basal secretion of cortisol and DHEAS was nonspecific among the various responder groups.
CONCLUSION
It seems that there is no close relationship between central opioid tone and adrenal function in hypothalamic amenorrhea.
目的
在一项促排卵研究中，我们通过使用纳洛酮来研究下丘脑性闭经女性下丘脑 - 垂体 - 肾上腺轴的活性和反应性。
方法
通过每天静脉注射4毫克纳洛酮推注来阻断中枢阿片受体。
结果
在受体阻断前后，皮质醇分泌呈现出与下丘脑阿片类物质张力无关的不同结果。皮质醇水平未升高。此外，皮质醇和脱氢表雄酮的基础分泌在不同反应组之间不具有特异性。
结论
在下丘脑性闭经中，中枢阿片类物质张力与肾上腺功能之间似乎没有密切关系。
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