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一种罕见的心脏黏液样平滑肌肉瘤。

An unusual myxoid leiomyosarcoma of the heart.

作者信息

Pucci A, Gagliardotto P, Papandrea C, Di Rosa E, Morello M, di Summa M, Mollo F

机构信息

Department of Biomedical Sciences, University of Turin, Italy.

出版信息

Arch Pathol Lab Med. 1996 Jun;120(6):583-6.

PMID:8651863
Abstract

We report a case of myxoid leiomyosarcoma originating from the interventricular septum in the outflow tract of the right ventricle. Although the gross features suggested a benign myxoma, histologic examination demonstrated features of a smooth muscle tumor, which was characterized by low mitotic index and a bland degree of atypia with few cells immunoreactive for cell cycle-associated Ki-67 antigen. The tumor relapsed twice, and the patient (a 61-year-old woman) died 18 months after the first diagnosis. This case demonstrates that myxoid leiomyomatous proliferations of the heart must be considered potentially malignant, even when the gross features and degree of cellular atypia seem to suggest otherwise.

摘要

我们报告一例起源于右心室流出道室间隔的黏液样平滑肌肉瘤。尽管大体特征提示为良性黏液瘤,但组织学检查显示为平滑肌肿瘤特征,其特点是有丝分裂指数低、异型性程度温和,仅有少数细胞对细胞周期相关的Ki-67抗原呈免疫反应阳性。该肿瘤复发两次,患者(一名61岁女性)在首次诊断后18个月死亡。该病例表明,心脏的黏液样平滑肌瘤样增生即使在大体特征和细胞异型性程度似乎提示为良性时,也必须被视为具有潜在恶性。

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