特应性皮炎炎症的新视角。
New perspectives on inflammation in atopic dermatitis.
作者信息
Kemp A S, Campbell D E
机构信息
Department of Immunology, Royal Children's Hospital, Parkville, Victoria, Australia.
出版信息
J Paediatr Child Health. 1996 Feb;32(1):4-6. doi: 10.1111/j.1440-1754.1996.tb01530.x.
Recent information implicates the stimulation of T cells by Staphylococcus aureus antigens and exotoxins as a likely factor in provoking the inflammatory response in atopic dermatitis. S. aureus secrets exotoxins called superantigens, which stimulate a large proportion of T cells. In addition, protein A, a component of the cell wall of S. aureus, is a potent B cell mitogen. This understanding provides a rationale for attempting to reduce the staphylococcal skin colonization of patients with severe atopic dermatitis and correlates with the clinical observation in a number of situations of marked improvement in atopic dermatitis following antibiotic treatment.
最近的信息表明，金黄色葡萄球菌抗原和外毒素对T细胞的刺激可能是引发特应性皮炎炎症反应的一个因素。金黄色葡萄球菌分泌称为超抗原的外毒素，可刺激很大比例的T细胞。此外，金黄色葡萄球菌细胞壁的一种成分蛋白A是一种有效的B细胞促有丝分裂原。这一认识为试图减少重度特应性皮炎患者的葡萄球菌皮肤定植提供了理论依据，并且与抗生素治疗后特应性皮炎在许多情况下显著改善的临床观察结果相关。
Zotero 插件