[炔雌醇甲醚对家兔非那宗药代动力学的影响]
[Effect of mestranol on pharmacokinetics of phenazone in the rabbit].
作者信息
Gawrońska-Szklarz B, Droździk M, Kwiatkowski A, Wójcicki J
机构信息
Zakładu Farmakologii Klinicznej PAM w Szczecinie.
出版信息
Ginekol Pol. 1996 Jan;67(1):1-6.
PMID:8655012
Abstract
There was studied the influence of mestranol on the pharmacokinetics parameters of phenazone. There was proved the decrease AUC abridgement the period of semi duration for elimination phase and increase total clearance. On the base of these experiments there was able to make a conclusion that estrogens influence on the phenazone's pharmacokinetic probably by induction of microsomal enzymes of liver.
摘要
研究了炔雌醇对非那宗药代动力学参数的影响。结果证明，炔雌醇可降低曲线下面积（AUC），缩短消除相的半衰期，并增加总清除率。基于这些实验，可以得出结论：雌激素可能通过诱导肝脏微粒体酶来影响非那宗的药代动力学。
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