肾上皮细胞中钠钙交换的鉴定及反义抑制
Identification and antisense inhibition of Na-Ca exchange in renal epithelial cells.
作者信息
White K E, Gesek F A, Friedman P A
机构信息
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755-3835, USA.
出版信息
Ann N Y Acad Sci. 1996 Apr 15;779:115-8. doi: 10.1111/j.1749-6632.1996.tb44776.x.
Abstract
In summary, DCT cells express multiple isoforms of the Na-Ca exchanger and exhibit functional exchange, and antisense oligonucleotides to a downstream region of the exchanger transcript inhibit activity. These experiments provide direct evidence for Na-Ca exchange in DCT cells mediated by NACA2, NACA3, or NACA6.
摘要
总之，远曲小管细胞表达钠钙交换体的多种亚型并表现出功能性交换，针对交换体转录本下游区域的反义寡核苷酸可抑制其活性。这些实验为NACA2、NACA3或NACA6介导的远曲小管细胞钠钙交换提供了直接证据。
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