多西他赛（泰索帝）对人胃癌的体内外抗肿瘤作用评估。

Evaluation of antitumour effects of docetaxel (Taxotere) on human gastric cancers in vitro and in vivo.

作者信息

Tanaka M, Obata T, Sasaki T

机构信息

Department of Experimental Therapeutics, Kanazawa University, Takaramachi, Japan.

出版信息

Eur J Cancer. 1996 Feb;32A(2):226-30. doi: 10.1016/0959-8049(95)00500-5.

DOI:10.1016/0959-8049(95)00500-5

PMID:8664032

Abstract

In vitro antitumour effects of docetaxel (Taxotere) were examined in nine cultured human gastric cancer cell lines and 18 clinical gastric cancer specimens. In vivo antitumour effects were examined in human gastric cancer xenografts in nude mice. The activity was compared with paclitaxel (Taxol). Docetaxel was more effective than paclitaxel in six of the nine cell lines and the effectiveness rates of docetaxel and paclitaxel were 56% (10/18) and 6% (1/17), respectively, in the clinical gastric cancer specimens. In vivo docetaxel showed superior antitumour effect on well differentiated (MKN-28), poorly differentiated (MKN-45) and undifferentiated (KKLS) gastric cancer xenografts. We conclude that docetaxel promises to be clinically active against gastric carcinomas.

摘要

在9种培养的人胃癌细胞系和18份临床胃癌标本中检测了多西他赛（泰索帝）的体外抗肿瘤作用。在裸鼠人胃癌异种移植模型中检测了其体内抗肿瘤作用。将该活性与紫杉醇（泰素）进行比较。在9种细胞系中的6种中，多西他赛比紫杉醇更有效，在临床胃癌标本中，多西他赛和紫杉醇的有效率分别为56%（10/18）和6%（1/17）。在体内，多西他赛对高分化（MKN-28）、低分化（MKN-45）和未分化（KKLS）胃癌异种移植模型显示出更强的抗肿瘤作用。我们得出结论，多西他赛有望对胃癌具有临床活性。