胰岛素样生长因子-I调节单核细胞与EAhy 926内皮细胞的黏附。
Insulin-like growth factor-I modulates monocyte adhesion to EAhy 926 endothelial cells.
作者信息
Motani A, Forster L, Tull S, Anggård E E, Ferns G A
机构信息
William Harvey Research Institute, London, UK.
出版信息
Int J Exp Pathol. 1996 Feb;77(1):31-5. doi: 10.1046/j.1365-2613.1996.960098.x.
IGF-I is a ubiquitous growth factor, found in platelets and elaborated by many other cell types. It is thought to be involved in several pathophysiological processes including embryonic development, angiogenesis and wound healing. We report that the adherence of human peripheral blood monocytes to an endothelial cell line (EAhy 926) is inhibited in a dose and time-dependent manner by pre-incubating the endothelial cells with IGF-I (P < 0.001). Monocyte adhesion was inhibited 17.9 +/- 1.9% by IGF-I at a dose of 1000 ng/ml (P < 0.01). In contrast, IGF-I had no significant effect on monocyte adherence to plastic. The inhibitory effects of IGF-I were reversed by co-incubating the endothelial cells with the nitric oxide synthase inhibitor, L-NAME. These data suggest that the effects of IGF-I are mediated by the release of nitric oxide from the endothelial cells.
胰岛素样生长因子-I（IGF-I）是一种广泛存在的生长因子，存在于血小板中，并由许多其他细胞类型分泌。它被认为参与了多种病理生理过程，包括胚胎发育、血管生成和伤口愈合。我们报告，通过用IGF-I预孵育内皮细胞，人外周血单核细胞与内皮细胞系（EAhy 926）的黏附以剂量和时间依赖性方式受到抑制（P < 0.001）。在1000 ng/ml的剂量下，IGF-I使单核细胞黏附受到17.9 +/- 1.9%的抑制（P < 0.01）。相反，IGF-I对单核细胞黏附到塑料上没有显著影响。通过将内皮细胞与一氧化氮合酶抑制剂L-NAME共同孵育，IGF-I的抑制作用被逆转。这些数据表明，IGF-I的作用是由内皮细胞释放一氧化氮介导的。
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