Law M G, Rosenberg P S, McDonald A, Kaldor J M
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW.
Med J Aust. 1996 Jun 17;164(12):715-8. doi: 10.5694/j.1326-5377.1996.tb122268.x.
To estimate age at HIV infection among homosexually active men in Australia.
Age-specific back-projection estimates of HIV incidence.
Monthly counts of AIDS among homosexually active men diagnosed by 30 June 1994 and reported by 31 March 1995 were obtained from the National AIDS Registry and were adjusted for reporting delays. The progression rate to AIDS was estimated from a large cohort study of HIV-infected homosexual men, with adjustment for the effect of age at HIV infection and the effect of antiretroviral and prophylactic treatments.
The median age at HIV infection was estimated to have decreased from 31 years of age between 1982 and 1984 to between 23 and 27 years in the periods 1987 to 1989 and 1990 to 1994. Despite the trend to a younger median age at HIV infection during the current epidemic, HIV incidence was estimated to have declined in all age groups from a peak in the mid-1980s. This decline was more pronounced in the older age groups, with more modest reductions in age groups under 30 years.
Most HIV infections among homosexually active men since 1987 appear to have occurred in men aged under 30 years. This has implications for education programs aimed at preventing HIV infection among homosexually active men.
估算澳大利亚男同性恋活跃人群感染艾滋病毒的年龄。
按年龄特异性反向推算艾滋病毒发病率。
从国家艾滋病登记处获取1994年6月30日前确诊并于1995年3月31日前上报的男同性恋活跃人群中艾滋病的月度病例数,并对报告延迟进行了调整。根据一项对感染艾滋病毒的男同性恋者的大型队列研究估算艾滋病进展率,并对感染艾滋病毒时的年龄影响以及抗逆转录病毒和预防性治疗的影响进行了调整。
据估计,感染艾滋病毒的中位年龄已从1982年至1984年的31岁降至1987年至1989年以及1990年至1994年期间的23至27岁。尽管在当前疫情期间感染艾滋病毒的中位年龄呈年轻化趋势,但据估计,所有年龄组的艾滋病毒发病率自20世纪80年代中期达到峰值后均有所下降。年龄较大的年龄组下降更为明显,30岁以下年龄组的下降幅度较小。
自1987年以来,男同性恋活跃人群中的大多数艾滋病毒感染似乎发生在30岁以下的男性中。这对旨在预防男同性恋活跃人群感染艾滋病毒的教育项目具有启示意义。