继发于第四脑室室管膜下瘤的发作性睡病。
Narcolepsy secondary to fourth ventricular subependymoma.
作者信息
Ma T K, Ang L C, Mamelak M, Kish S J, Young B, Lewis A J
机构信息
Division of Pathology, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
出版信息
Can J Neurol Sci. 1996 Feb;23(1):59-62. doi: 10.1017/s0317167100039202.
BACKGROUND
Secondary (symptomatic) narcolepsy is rare. We report a subependymoma of the fourth ventricle associated with narcolepsy. The patient was a 50-year old woman with a long history of narcolepsy who died of colonic carcinoma with no cerebral metastasis. She was positive for HLA-DR2. At autopsy there was a tumour dorsal to the fourth ventricle which involved the midbrain tectum and rostral pons. Histologic examination of the tumour confirmed it to be a subependymoma.
METHODS
Review of the previous cases of secondary narcolepsy was made with particular reference to the anatomical location of the lesions.
RESULTS
Most of the lesions were found around the third ventricle and rostral brainstem.
CONCLUSIONS
Knowing the anatomical localization of the pathological changes in secondary narcolepsy could be important in improving our understanding of its pathogenesis.
背景
继发性（症状性）发作性睡病较为罕见。我们报告一例与发作性睡病相关的第四脑室室管膜下瘤。患者为一名50岁女性，有发作性睡病病史较长，死于无脑转移的结肠癌。她的人类白细胞抗原DR2呈阳性。尸检时发现第四脑室背侧有一个肿瘤，累及中脑顶盖和脑桥嘴侧。肿瘤的组织学检查证实为室管膜下瘤。
方法
回顾了既往继发性发作性睡病病例，特别参考了病变的解剖位置。
结果
大多数病变位于第三脑室和脑桥嘴侧周围。
结论
了解继发性发作性睡病病理变化的解剖定位对于增进我们对其发病机制的理解可能很重要。
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