Harty J C, Boulton H, Venning M C, Gokal R
Renal Unit, Manchester Royal Infirmary, UK.
Miner Electrolyte Metab. 1996;22(1-3):97-101.
In light of the correlation between the dialysate to plasma ratio of creatinine (D/P Cr), peritoneal (PD) protein loss and hypoalbuminaemia, peritoneal permeability has been implicated as a risk factor for malnutrition in CAPD patients. However, serum albumin is also affected by hydration which is itself influenced by peritoneal permeability. In a cross-sectional study of 147 CAPD patients we investigated the relationship between peritoneal permeability, PD protein loss and nutritional state. Stepwise regression analysis revealed D/P Cr to be the only significant predictor of serum albumin independent of PD protein loss. No significant relationship was demonstrated between D/P Cr, body fat, lean muscle mass and dietary protein intake. Increased peritoneal permeability does not cause hypoalbuminaemia as a consequence of increased PD protein loss, and does not adversely affect somatic fat and protein status.
鉴于肌酐透析液与血浆比值（D/P Cr）、腹膜（PD）蛋白丢失和低白蛋白血症之间的相关性，腹膜通透性被认为是持续性非卧床腹膜透析（CAPD）患者营养不良的一个危险因素。然而，血清白蛋白也受水合作用影响，而水合作用本身又受腹膜通透性影响。在一项对147例CAPD患者的横断面研究中，我们调查了腹膜通透性、PD蛋白丢失与营养状况之间的关系。逐步回归分析显示，D/P Cr是独立于PD蛋白丢失之外血清白蛋白的唯一显著预测指标。未发现D/P Cr、体脂、瘦肌肉量和膳食蛋白质摄入量之间存在显著关系。腹膜通透性增加不会因PD蛋白丢失增加而导致低白蛋白血症，也不会对体脂和蛋白质状况产生不利影响。
