Förstl H, Besthorn C, Sattel H, Zerfass R, Geiger-Kabisch C, Schreiter-Gasser U, Hentschel F
Zentralinstitut für Seelische Gesundheit, Mannheim.
Nervenarzt. 1996 Jan;67(1):53-61.
We studied (1) the differences of volumetric estimates of brain atrophy in normal ageing and Alzheimer's disease (AD); (2) the correlation of these estimates with age and cognitive performance; (3) the differences between absolute EEG power between ageing and AD; (4) the correlation between EEG power and age or cognitive performance; and (5) the correlation between volumetric and EEG data. 84 patients with a clinical diagnosis of AD and 45 age-approximated non-demented controls between 48 and 91 years of age were examined. For statistical comparisons the volumetric estimates of intracranial cerebrospinal fluid (csf) spaces were converted into percentages of total intracranial volume. The EEG was recorded from 17 locations at resting conditions, eyes closed, according to the 10/20 system. Logtransformed absolute band powers were compared between the AD and control groups and correlated with clinical and volumetric findings. The total intracranial csf-space, both lateral ventricles, the third ventricle, anterior, lateral and posterior fissures were significantly larger in AD than in non-demented controls. In normal ageing the csf-volumes were significantly correlated with age, whereas age and cognitive performance were differentially correlated with these variables in AD. In AD, the absolute delta or theta power was significantly higher in all locations, whereas alpha power was lower than in normal controls. These differences were significantly correlated with cognitive performance. There were no significant correlations between the csf-volumes and EEG-power in AD and the control group with one exception: we found a significant inverse correlation between the volumes of the anterior and posterior fissure and the alpha-1 and alpha-2 power independent of electrode location in AD. We conclude that the morphological and EEG-changes in AD are largely independent and suggest that the functional relationship between alpha-power and anterior or posterior fissure volume needs further examination.
（1）正常衰老和阿尔茨海默病（AD）中脑萎缩体积估计值的差异；（2）这些估计值与年龄和认知表现的相关性；（3）衰老和AD之间绝对脑电图功率的差异；（4）脑电图功率与年龄或认知表现的相关性；以及（5）体积数据和脑电图数据之间的相关性。对84例临床诊断为AD的患者和45例年龄在48至91岁之间的年龄相近的非痴呆对照者进行了检查。为了进行统计学比较，将颅内脑脊液（CSF）间隙的体积估计值转换为颅内总体积的百分比。根据10/20系统，在闭眼静息状态下从17个部位记录脑电图。比较AD组和对照组之间经对数转换的绝对频段功率，并将其与临床和体积测量结果相关联。AD患者的颅内总CSF间隙、双侧脑室、第三脑室、前、外侧和后裂均显著大于非痴呆对照者。在正常衰老过程中，CSF体积与年龄显著相关，而在AD中，年龄和认知表现与这些变量的相关性不同。在AD中，所有部位的绝对δ或θ功率均显著更高，而α功率低于正常对照者。这些差异与认知表现显著相关。AD组和对照组中CSF体积与脑电图功率之间无显著相关性，但有一个例外：我们发现AD患者中前、后裂的体积与α1和α2功率之间存在显著的负相关，且与电极位置无关。我们得出结论，AD中的形态学和脑电图变化在很大程度上是独立的，并表明α功率与前或后裂体积之间的功能关系需要进一步研究。
