Rodriguez J, Point D, Brunin F, Jaulerry C, Brugère J
Service de chirurgie cervicofaciale et ORL, Institut Curie, Paris, France.
Bull Cancer Radiother. 1996;83(1):17-23.
Changes in surgical procedures for hypopharynx cancer after definitive radiotherapy are important since the use of pedicled myocutanous flaps and free digestive transplants. Postoperative course is improved and salvage surgery more frequent. From 1970 to 1990, 160 hypopharyngeal carcinomas were operated on after radiotherapy, 103 due to failures or complications after definitive irradiation and 57 metachronous cancers. During this period, the rate of lethal postoperative complications decreased from 25% to 8%. Crude survival rates are 51% at 1 year, 22% at 3 years and 15% at 5 years. Poor prognostic features are local extension, positive margins and extracapsular nodal spread. Postoperative deaths and failures in primary or neck account for 60% of the causes of death. Results of salvage surgery are unsatisfactory: the choice of definitive radiotherapy with surgery in reserve must be restricted to selected cases.
自从带蒂肌皮瓣和游离消化器官移植开始应用以来,下咽癌根治性放疗后的手术方式变化具有重要意义。术后病程得到改善,挽救性手术更为常见。1970年至1990年期间,160例下咽癌患者在放疗后接受了手术,其中103例是由于根治性照射后出现失败或并发症,57例是异时性癌。在此期间,术后致命并发症的发生率从25%降至8%。1年、3年和5年的粗生存率分别为51%、22%和15%。预后不良的特征包括局部扩展、切缘阳性和包膜外淋巴结转移。术后死亡以及原发灶或颈部的复发占死亡原因的60%。挽救性手术的结果并不理想:将根治性放疗并保留手术作为备选方案的选择必须仅限于特定病例。