Ellend A, Obwegeser R, Auerbach L, Czerwenka K, Kubista E
Abteilung für Spezielle Gynäkologie, Universitätsfrauenklinik, AKH-Wien.
Geburtshilfe Frauenheilkd. 1996 Apr;56(4):209-13. doi: 10.1055/s-2007-1022261.
S.R., a 66-year old woman, was referred to our department because of an axillary mass in the right side. The patient had observed an increasing, painless swelling in the right axilla for the last two months. In the region of the right axilla in the middle axillary line an ovoid and solid tumour of 3 cm in diameter, quite well distinguishable, moving against the skin and the surrounding tissue, could be palpated. A subsequent mammography yielded an unsuspicious visualisation of both breasts and the left axilla. In the right axilla a circular solidification was detected, which then turned out on ultrasound examination to be a 2.6-cm diameter axillary lymph node. In the course of the lymph node extirpation of the right axilla two lymph nodes were dissected with histological evidence of metastatic nodes of a solid tumour, most likely in accordance with a breast carcinoma. Several immunohistochemical methods had been applied to determine the origin of the tumour cells and were thus identified as breast cancer cells. To detect primary causative carcinoma, different examinations were performed postoperatively without identifying any cancerous lesions. At least accurate research concerning the history of the patient was required to reexamine the histologic material of an operation of the right breast in 1989. The histological diagnosis of the dissected node of that time had been defined as a benign intracanaliculary papilloma in the right side without evidence of malignancy. The reexamination of the paraffin-embedded material from the operation of the right breast in 1989 revealed a lobular carcinoma of the right breast. The "occult" (undetectable) carcinoma of the breast occurs in less than 1% of all breast carcinomas. Thus it represent a rare clinical event and hence no standardised therapy schemata exist. To confirm the diagnosis of an occult carcinoma of the breast efficient reexamination of histological material from earlier breast operations indicated.
S.R.是一位66岁的女性,因右侧腋窝肿块被转诊至我院。患者在过去两个月中发现右侧腋窝无痛性肿胀且逐渐增大。在腋中线右侧腋窝区域可触及一个直径3厘米的椭圆形实性肿瘤,边界清晰,可在皮肤及周围组织间移动。随后的乳腺钼靶检查显示双侧乳房及左侧腋窝未见异常。右侧腋窝发现一个圆形致密影,超声检查证实为一个直径2.6厘米的腋窝淋巴结。在右侧腋窝淋巴结切除术中,切除了两个淋巴结,组织学检查显示为实性肿瘤转移淋巴结,很可能源自乳腺癌。应用多种免疫组化方法确定肿瘤细胞来源,确诊为乳腺癌细胞。为检测原发性癌,术后进行了多项检查,但未发现任何癌性病变。为重新检查1989年右侧乳房手术的组织学材料,至少需要对患者病史进行准确调查。当时切除淋巴结的组织学诊断为右侧良性管内乳头状瘤,无恶性证据。对1989年右侧乳房手术石蜡包埋材料的重新检查发现为右侧小叶癌。“隐匿性”(不可检测)乳腺癌在所有乳腺癌中发生率低于1%。因此这是一种罕见的临床情况,目前尚无标准化治疗方案。为确诊隐匿性乳腺癌,建议对早期乳房手术的组织学材料进行有效重新检查。