Haque T, Thomas J A, Falk K I, Parratt R, Hunt B J, Yacoub M, Crawford D H
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, UK.
J Gen Virol. 1996 Jun;77 ( Pt 6):1169-72. doi: 10.1099/0022-1317-77-6-1169.
Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD). To determine whether the donor EBV isolate is transmitted to the recipient via the allograft and causes PTLD, EBV isolates from four cases of PTLD in cadaveric heart and/or lung transplant recipients were compared with the donor isolates by PCR and DNA sequence analysis. Two recipients who were EBV seronegative at transplantation acquired an EBV isolate indistinguishable from that of the donor and developed PTLD. In contrast, in two patients who were seropositive before transplantation, the donor isolate differed from that present in PTLD of the recipient. The results suggest that the acquisition of donor EBV is a risk factor for PTLD development in a previously seronegative transplant recipient.
爱泼斯坦-巴尔病毒（EBV）与移植后淋巴细胞增生性疾病（PTLD）相关。为了确定供体EBV分离株是否通过同种异体移植物传播给受体并导致PTLD，通过PCR和DNA序列分析，将4例尸体心脏和/或肺移植受者的PTLD病例中的EBV分离株与供体分离株进行了比较。两名移植时EBV血清学阴性的受者获得了与供体无法区分的EBV分离株，并发生了PTLD。相比之下，在两名移植前血清学阳性的患者中，供体分离株与受体PTLD中存在的分离株不同。结果表明，在先前血清学阴性的移植受者中，获得供体EBV是发生PTLD的一个危险因素。
