Tokarskaia Z B, Okladnikova N D, Beliaeva Z D, Aristov V P
Vopr Onkol. 1996;42(1):43-7.
Adenocarcinoma frequency in Pu incorporation-related lung cancer patients among plutonium workers was found to be 74% versus 33% in control. Each histological pattern of lung cancer appeared to be related to several etiological factors but in varying degree. Incorporated Pu proved the strongest factor in adenocarcinoma development. Its odds ratio (OR) was 6.9, while that for smoking-4.3. However, smoking appeared to be the most significant factor in squamous cell carcinoma genesis (OR-6.8). Among other factors were chronic obstructive pathology of the lung (OR-3.9) and reduced body weight (OR-2.1). The OR for Pu incorporation was 3.9. Squamous cell carcinomas were traced to reduced body weight (OR-2.9), heavy smoking (smoking index more than 500) (OR-3.5). However, no significant relationship has been established between carcinogenesis and Pu incorporation.
钚作业工人中，钚摄入相关肺癌患者的腺癌发生率为74%，而对照组为33%。肺癌的每种组织学类型似乎都与多种病因相关，但程度不同。摄入的钚被证明是腺癌发生的最强因素。其优势比（OR）为6.9，而吸烟的优势比为4.3。然而，吸烟似乎是鳞状细胞癌发生的最重要因素（OR为6.8）。其他因素包括慢性阻塞性肺疾病（OR为3.9）和体重减轻（OR为2.1）。钚摄入的OR为3.9。鳞状细胞癌与体重减轻（OR为2.9）、大量吸烟（吸烟指数超过500）（OR为3.5）有关。然而，在致癌作用与钚摄入之间尚未建立显著关系。
