Guanes P P, Remohí J, Gallardo E, Valbuena D, Simón C, Pellicer A
Instituto Valenciano de Infertilidad and Valencia University School of Medicine, Spain.
Fertil Steril. 1996 Aug;66(2):265-70. doi: 10.1016/s0015-0282(16)58451-9.
To determine whether uterine vasculature is affected by age using oocyte donation as an in vivo model.
Prospective longitudinal study in which recipients were grouped according to age. They underwent a successful oocyte donation cycle, and single pregnancies were followed during the first trimester by color Doppler ultrasound in uterine arteries.
Oocyte donation and IVF program at the Instituto Valenciano de Infertilidad.
Serum E2, P, and hCG levels in single ovum donation pregnancies; pulsatility and resistance indexes in uterine arteries during initial pregnancy.
Similar serum levels of E2, P, and hCG in both groups of patients were observed. There was no difference between groups regarding the flow indexes analyzed.
The increased incidence of early pregnancy losses observed in patients > 40 years cannot be attributed to defective response of uterine vasculature to exogenous hormone replacement. Thus, uterine aging does not appear to be a factor influencing the poor reproductive performance of women with advancing age.
以卵母细胞捐赠作为体内模型，确定子宫血管系统是否受年龄影响。
前瞻性纵向研究，根据年龄对受者进行分组。她们经历了成功的卵母细胞捐赠周期，单胎妊娠在孕早期通过子宫动脉彩色多普勒超声进行监测。
瓦伦西亚不育症研究所的卵母细胞捐赠与体外受精项目。
单卵捐赠妊娠中的血清E2、P和hCG水平；孕早期子宫动脉的搏动指数和阻力指数。
两组患者的血清E2、P和hCG水平相似。在分析的血流指数方面，两组之间没有差异。
40岁以上患者中观察到的早期妊娠丢失发生率增加，不能归因于子宫血管系统对外源性激素替代的反应缺陷。因此，子宫老化似乎不是影响高龄女性生殖性能不佳的一个因素。
