Ohshima K, Kikuchi M
Department of Pathology, School of Medicine, Fukuoka University, Japan.
Rinsho Byori. 1996 Jan;44(1):24-31.
Epstein-Barr virus (EBV), a DNA virus of the herpes virus family can infect and transform resting human B lymphocytes in vitro. EBV was originally considered to be a possible causative agent of African Burkitt's lymphoma and nasopharyngeal lymphoepithelioma. Recently, using highly sensitive methods, such as the polymerase chain reaction (PCR) and in situ hybridization (ISH), EBV has been found to be also present in numerous human lymphoproliferative disorders, including Hodgkin's disease, anaplastic large cell lymphoma, B cell lymphoma in immunocompromised patients, peripheral T cell lymphoma, adult T cell leukemia/lymphoma, nasal lymphoma, AILD-T cell lymphoma, pyothorax-associated pleural lymphoma, and angiocentric T/NK cell lymphoma. However, the EBV infection pattern and the role of EBV in each disease is not the same. We introduce the relationship between EBV and each disease found in our department, using Southern blot analysis, PCR, ISH and immunological staining.
爱泼斯坦-巴尔病毒（EBV）是一种疱疹病毒科的DNA病毒，它能够在体外感染并转化静息的人类B淋巴细胞。EBV最初被认为可能是非洲伯基特淋巴瘤和鼻咽淋巴上皮瘤的致病因子。最近，通过使用聚合酶链反应（PCR）和原位杂交（ISH）等高灵敏度方法，人们发现EBV也存在于众多人类淋巴增殖性疾病中，包括霍奇金病、间变性大细胞淋巴瘤、免疫功能低下患者中的B细胞淋巴瘤、外周T细胞淋巴瘤、成人T细胞白血病/淋巴瘤、鼻淋巴瘤、AILD-T细胞淋巴瘤、脓胸相关胸膜淋巴瘤以及血管中心性T/NK细胞淋巴瘤。然而，EBV的感染模式以及EBV在每种疾病中的作用并不相同。我们运用Southern印迹分析、PCR、ISH和免疫染色等方法，介绍了我们科室所发现的EBV与每种疾病之间的关系。
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