Corda D, Falasca M
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Laboratory of Cellular and Molecular Endocrinology, Santa Maria Imbaro (Chieti), Italy.
Anticancer Res. 1996 May-Jun;16(3B):1341-50.
Glycerophosphoinositols are metabolites formed by the sequential action of a phospholipase A2 specific for membrane phosphoinositides, and a lysolipase. Increased levels of these compounds characterize cell lines of different origin transformed by ras and other oncogenes. Thus, glycerophosphoinositols have been proposed as markers of cell transformation. These compounds are also biologically active. In particular, glycerophosphoinositol-4-phosphate (GroPIns4P) is an inhibitor of adenylyl cyclase that acts on the Gs protein. Since GroPIns4P is formed physiologically upon hormone stimulation in several cell lines including fibroblasts, thyrocytes, neuronal and leukemia cells, we propose that GroPIns4P could act as a second messenger able to mediate a cross-talk between the ras cascade and adenylyl cyclase.
甘油磷酸肌醇是由对膜磷酸肌醇具有特异性的磷脂酶A2和溶血磷脂酶依次作用形成的代谢产物。这些化合物水平的升高是由ras和其他致癌基因转化的不同来源细胞系的特征。因此，甘油磷酸肌醇被提议作为细胞转化的标志物。这些化合物也具有生物活性。特别地，甘油磷酸肌醇-4-磷酸（GroPIns4P）是一种作用于Gs蛋白的腺苷酸环化酶抑制剂。由于GroPIns4P在包括成纤维细胞、甲状腺细胞、神经元细胞和白血病细胞在内的几种细胞系中受到激素刺激后在生理条件下形成，我们提出GroPIns4P可能作为一种第二信使，能够介导ras级联反应和腺苷酸环化酶之间的串扰。
