倍半萜内酯。十九。作用方式的初步研究。对肿瘤细胞蛋白质和RNA合成的抑制作用
Sesquiterpene lactones. XIX. Preliminary studies on the mode of action. Inhibition of synthesis of tumor cell protein and RNA.
作者信息
Hladoń B, Bobkiewicz T, Drozdz B
出版信息
Arch Immunol Ther Exp (Warsz). 1977;25(2):243-51.
The isotopic examinations of the mode of action of cytostatic active acid 8a-isobuetyric-14,15-dihydroxy-germacran-1 (10),4,11(13)-trienolide 12(6) (alatolide) have demonstrated that the compound at concentration 5-6 X 10(-5) M induces defective changes in HeLa cells resulting in the inhibition of protein synthesis in 93-8% and RNA in 91-9% and, in consequence, cell death. At lower concentrations 2-8 X 10(-6) M, the compound inhibits protein synthesis in 73% and RNA in 5-7%. The direct influence of alatolide on DNA synthesis is doubtful.
对具有细胞生长抑制活性的酸8a - 异丁酸 - 14,15 - 二羟基 - 吉马烷 - 1(10),4,11(13) - 三烯 - 12,6 - 内酯（阿拉托内酯）作用模式的同位素研究表明，该化合物在浓度为5 - 6×10⁻⁵ M时会在HeLa细胞中诱导缺陷性变化，导致蛋白质合成抑制93 - 98%，RNA合成抑制91 - 99%，进而导致细胞死亡。在较低浓度2 - 8×10⁻⁶ M时，该化合物抑制蛋白质合成73%，抑制RNA合成5 - 7%。阿拉托内酯对DNA合成的直接影响尚不确定。
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