CLAPS3基因的克隆、表达模式及定位于12号染色体短臂13.2至13.1区域，该基因编码一种新型网格蛋白衔接小链。

Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain.

作者信息

Watanabe T K, Shimizu F, Nagata M, Takaichi A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y

机构信息

Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.

出版信息

Cytogenet Cell Genet. 1996;73(3):214-7. doi: 10.1159/000134341.

DOI:10.1159/000134341

PMID:8697810

Abstract

From a human fetal-brain cDNA library we isolated a novel gene encoding a peptide homologous to clathrin-adaptor small chains in rat, mouse, and yeast. The cDNA, designated CLAPS3 (clathrin-associated/assembly/adaptor protein, small 3, 22 kDa), contained an open reading frame of 579 nucleotides encoding 193 amino acids. Northern-blot analysis revealed expression of a 1.35-kb transcript in all human tissues examined. This gene was mapped to chromosome bands 12p13.2 --> p13.1 by FISH.

摘要

我们从一个人类胎儿脑cDNA文库中分离出一个新基因，该基因编码一种与大鼠、小鼠和酵母中的网格蛋白衔接小链同源的肽。该cDNA被命名为CLAPS3（网格蛋白相关/组装/衔接蛋白，小3，22 kDa），包含一个579个核苷酸的开放阅读框，编码193个氨基酸。Northern杂交分析显示，在所检测的所有人类组织中均有一个1.35 kb转录本的表达。通过荧光原位杂交（FISH）将该基因定位于染色体12p13.2→p13.1带。