Wichmann M W, Zellweger R, DeMaso C M, Ayala A, Chaudry I H
Department of Surgery, Michigan State University, East Lansing 48824-1315, USA.
Experientia. 1996 Jun 15;52(6):587-90. doi: 10.1007/BF01969734.
Although hemorrhagic shock leads to significant alterations of several hormones, e.g. ACTH, corticosterone and beta-endorphin, it is not known whether plasma melatonin levels are affected under this condition and if so, whether the effects are comparable in males and females. Using a radioimmunoassay, it was found that plasma melatonin levels were significantly increased in male and proestrus female C3H/HeN mice immediately after hemorrhagic shock. However, in male mice, by two hours after hemorrhage and resuscitation, plasma melatonin returned to levels comparable to those seen in control and sham-operated animals. Proestrus female mice, on the other hand, showed significantly increased plasma melatonin levels at two hours after surgery when compared to unoperated control animals. Although the significance and biological role of the transient increased plasma melatonin levels after hemorrhagic shock remain to be determined, it appears that the pineal gland and/or an extrapineal source of melatonin, of both male and proestrus female mice responds to severe hypotension by increased release of melatonin.
尽管失血性休克会导致多种激素发生显著变化，如促肾上腺皮质激素、皮质酮和β-内啡肽，但尚不清楚在此种情况下血浆褪黑素水平是否会受到影响，若受影响，其在雄性和雌性动物中的作用是否相同。通过放射免疫分析法发现，失血性休克后，雄性和处于动情前期的雌性C3H/HeN小鼠的血浆褪黑素水平立即显著升高。然而，对于雄性小鼠，出血和复苏两小时后，血浆褪黑素水平恢复至与对照和假手术动物相当的水平。另一方面，与未手术的对照动物相比，处于动情前期的雌性小鼠在手术后两小时血浆褪黑素水平显著升高。尽管失血性休克后血浆褪黑素水平短暂升高的意义和生物学作用尚待确定，但似乎雄性和处于动情前期的雌性小鼠的松果体和/或褪黑素的松果体外来源会通过增加褪黑素的释放来应对严重低血压。
