伯克霍尔德菌假鼻疽亚种O-多糖-鞭毛蛋白缀合物的结构和免疫学特征
Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates.
作者信息
Brett P J, Woods D E
机构信息
Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary Health Sciences Centre, Alberta, Canada.
出版信息
Infect Immun. 1996 Jul;64(7):2824-8. doi: 10.1128/iai.64.7.2824-2828.1996.
Abstract
The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopolysaccharide was covalently linked to flagellin protein isolated from the same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This immunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.
摘要
伯克霍尔德菌假鼻疽亚种319a脂多糖的O-多糖部分与从同一菌株分离的鞭毛蛋白共价连接。一种结合己二酸二酰肼作为间隔分子的糖缀合物引发了针对该构建体蛋白质和碳水化合物成分的高滴度免疫球蛋白G反应。这种免疫球蛋白G能够保护糖尿病大鼠免受异源伯克霍尔德菌假鼻疽亚种菌株的攻击。
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