某些沙眼衣原体血清型主要外膜蛋白可变序列区4中并列存在着物种、血清群和血清型特异性表位。
Species-, serogroup-, and serovar-specific epitopes are juxtaposed in variable sequence region 4 of the major outer membrane proteins of some Chlamydia trachomatis serovars.
作者信息
Batteiger B E, Lin P M, Jones R B, Van Der Pol B J
机构信息
Department of Medicine, Indiana University School of Medicine, Indianapolis,
出版信息
Infect Immun. 1996 Jul;64(7):2839-41. doi: 10.1128/iai.64.7.2839-2841.1996.
Abstract
Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B-serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific epitopes. The carboxyl-terminal portion of variable sequence region 4 (residues 297 to 314) comprises a region of end-to-end B-cell epitopes in some serovars of the B and F/G serogroups.
摘要
合成肽和鼠单克隆抗体被用于绘制交叉反应性衣原体表位图谱。可变序列区域4中心区域的一个种特异性表位紧邻B血清群特异性或F/G血清群特异性表位的氨基末端，而该表位又紧邻已知的血清型特异性表位。可变序列区域4的羧基末端部分（第297至314位氨基酸残基）在B和F/G血清群的一些血清型中包含一个首尾相连的B细胞表位区域。
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