某些沙眼衣原体血清型主要外膜蛋白可变序列区4中并列存在着物种、血清群和血清型特异性表位。
Species-, serogroup-, and serovar-specific epitopes are juxtaposed in variable sequence region 4 of the major outer membrane proteins of some Chlamydia trachomatis serovars.
作者信息
Batteiger B E, Lin P M, Jones R B, Van Der Pol B J
机构信息
Department of Medicine, Indiana University School of Medicine, Indianapolis,
出版信息
Infect Immun. 1996 Jul;64(7):2839-41. doi: 10.1128/iai.64.7.2839-2841.1996.
Abstract
Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B-serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific epitopes. The carboxyl-terminal portion of variable sequence region 4 (residues 297 to 314) comprises a region of end-to-end B-cell epitopes in some serovars of the B and F/G serogroups.
摘要
合成肽和鼠单克隆抗体被用于绘制交叉反应性衣原体表位图谱。可变序列区域4中心区域的一个种特异性表位紧邻B血清群特异性或F/G血清群特异性表位的氨基末端，而该表位又紧邻已知的血清型特异性表位。可变序列区域4的羧基末端部分（第297至314位氨基酸残基）在B和F/G血清群的一些血清型中包含一个首尾相连的B细胞表位区域。
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1
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Infect Immun. 1996 Feb;64(2):542-7. doi: 10.1128/iai.64.2.542-547.1996.
2
Nucleotide sequence of the variable domains within the major outer membrane protein gene from serovariants of Chlamydia trachomatis.
Infect Immun. 1993 Jan;61(1):213-9. doi: 10.1128/iai.61.1.213-219.1993.
3
Workshop on in vitro neutralization of Chlamydia trachomatis: summary of proceedings.
J Infect Dis. 1993 Aug;168(2):415-20. doi: 10.1093/infdis/168.2.415.
4
Chlamydia trachomatis from individuals in a sexually transmitted disease core group exhibit frequent sequence variation in the major outer membrane protein (omp1) gene.
J Clin Invest. 1994 Jul;94(1):458-63. doi: 10.1172/JCI117347.
5
DNA sequence polymorphism of the Chlamydia trachomatis omp1 gene.
J Infect Dis. 1993 Nov;168(5):1225-30. doi: 10.1093/infdis/168.5.1225.
6
Mapping of a surface-exposed B-cell epitope to the variable sequent 3 of the major outer-membrane protein of Chlamydia trachomatis.
J Gen Microbiol. 1993 Jul;139(7):1565-70. doi: 10.1099/00221287-139-7-1565.
7
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8
Antibody recognition of a neutralization epitope on the major outer membrane protein of Chlamydia trachomatis.
Infect Immun. 1994 May;62(5):1576-83. doi: 10.1128/iai.62.5.1576-1583.1994.
9
Mimicry of a neutralizing epitope of the major outer membrane protein of Chlamydia trachomatis by anti-idiotypic antibodies.
Infect Immun. 1994 Feb;62(2):341-7. doi: 10.1128/iai.62.2.341-347.1994.
10
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.
Proc Natl Acad Sci U S A. 1984 Jul;81(13):3998-4002. doi: 10.1073/pnas.81.13.3998.
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