[豚鼠中普卢利沙星（NM441）的光致敏性研究]

[A photoallergenicity study of prulifloxacin (NM441) in guinea pigs].

作者信息

Kamata K, Ogawa A, Inoue T, Ishihara M, Ishimura K, Sumi N, Asaoka H, Shindo Y

机构信息

Gifu Research Laboratory, Center of Japan Biological Chemistry, Co., Ltd., Japan.

出版信息

J Toxicol Sci. 1996 Jun;21 Suppl 1:259-65. doi: 10.2131/jts.21.supplementi_259.

DOI:10.2131/jts.21.supplementi_259

PMID:8709166

Abstract

Photoallergenicity of prulifloxacin, a new antibacterial agent, was examined using guinea pigs compared with those of the other quinolone antibacterial drugs, ofloxacin (OFLX), lomefloxacin (LFLX), ciprofloxacin (CPFX), enoxacin (ENX) and nalidixic acid (NA). Prulifloxacin and other drugs were orally administered at minimal phototoxic doses 1 hr before UVA (18 J/cm2) irradiation. This photosensitization procedure was daily repeated for 5 days. On 16 days after the final sensitization, the animals were challenged with UVA (18 J/cm2) after the administration of correspondent substances at maximal non-phototoxic doses. Photoallergic reactions were induced by OFLX (40 mg/kg), LFLX (3 mg/kg), CPFX (170 mg/kg) and ENX (80 mg/kg), but were not observed in prulifloxacin (170 mg/kg) and NA (30 mg/kg). These results show that photoallergenicity of prulifloxacin were less severe than those of the other quinolone antibacterial drugs under the conditions of this study.

摘要

使用豚鼠研究了新型抗菌药物普拉氟沙星与其他喹诺酮类抗菌药物氧氟沙星（OFLX）、洛美沙星（LFLX）、环丙沙星（CPFX）、依诺沙星（ENX）和萘啶酸（NA）相比的光致敏性。在UVA（18 J/cm²）照射前1小时，以最小光毒性剂量口服给予普拉氟沙星和其他药物。该光致敏程序每天重复进行5天。在最后一次致敏后16天，在给予最大非光毒性剂量的相应物质后，用UVA（18 J/cm²）对动物进行激发。OFLX（40 mg/kg）、LFLX（3 mg/kg）、CPFX（170 mg/kg）和ENX（80 mg/kg）可诱导光过敏反应，但在普拉氟沙星（170 mg/kg）和NA（30 mg/kg）中未观察到。这些结果表明，在本研究条件下，普拉氟沙星的光致敏性比其他喹诺酮类抗菌药物轻。