Itakura T, Yamamoto K, Tohyama M, Shimizu N
Stroke. 1977 May-Jun;8(3):360-5. doi: 10.1161/01.str.8.3.360.
Fluorescence-and electron-microscopic studies were performed on nerve terminals close to intracerebral blood vessels in the rat. For the electron microscope subdural perfusion fixation with potassium permanganate was used. In the rat cerebral cortex deprived of the bilateral superior cervical ganglion some aminergic terminal boutons containing large and small core vesicles were observed contiguous to blood vessels. These terminals abutted on the capillary basement membrane. Since these terminals are found in the rat after bilateral superior cervical ganglion exision, they probably originate from central catecholaminergic neurons in the brain stem. These findings suggest that central aminergic neurons might play some role in cerebral blood flow regulation. In addition to aminergic terminal boutons, non-aminergic nerve terminals containing non-core vesicles also ended in the capillaries. Cerebral capillaries also have central dual innervation, aminergic and cholinergic, and dual peripheral innervation by sympathetic and parasympathetic fibers.
对大鼠脑内血管附近的神经末梢进行了荧光和电子显微镜研究。电子显微镜检查采用高锰酸钾硬膜下灌注固定法。在双侧颈上神经节切除的大鼠大脑皮层中，观察到一些含有大小不同核心小泡的胺能终末小体与血管相邻。这些终末与毛细血管基底膜相邻。由于在双侧颈上神经节切除后的大鼠中发现了这些终末，它们可能起源于脑干中的中枢儿茶酚胺能神经元。这些发现表明中枢胺能神经元可能在脑血流调节中发挥某种作用。除了胺能终末小体外，含有非核心小泡的非胺能神经末梢也终止于毛细血管。脑毛细血管也有中枢双重神经支配，即胺能和胆碱能支配，以及外周交感和副交感纤维的双重神经支配。
